Canadian study on the Association of Pessary with Progesterone
Currently, the obstetric community believes that further studies are needed before using the pessary in hospitals that can prevent prematurity in the presence of a short cervix.
The Canadian Pessary to Progesterone (CAPP) study is the first study of the pessary in Canada that combines "Progesterone and Pessary" versus "Progesterone" for the prevention of prematurity in the presence of a short cervix.
Under the CAPP project, recruitment will be in 2 steps:
- Identification from cervical measurement by abdominal ultrasound (18–23 weeks of gestation)
- If the cervical measurement is ≤ 30 mm in transabdominal, check for the presence of a short cervix by endovaginal route with a more severe threshold of ≤ 25 mm.
- Goya M, Pratcorona L, Merced C, et al. Cervical pessary in pregnant women with a short cervix (PECEP): an open-label randomised controlled trial. Lancet 2012;379:1800-6.
- Nicolaides KH, Syngelaki A, Poon LC, et al. A Randomized Trial of a Cervical Pessary to Prevent Preterm Singleton Birth. NEJM 2016; 374:1044-1052.
- Hui AS, Lao TT, Ting YH, Leung TY. Cervical pessary in pregnant women with a short cervix. Lancet 2012;380:887.